Ap1 complex has been called a doubleedged sword in tumorigenesis. Ap 1 is a dimeric transcription factor that contains members from the jun, fos, atf and maf protein families. Rhomboid domain containing 1 inhibits cell apoptosis by. The textbook description that ap1 functions primarily as an oncogenic complex in tumorigenesis has to be revised on the basis of recent studies in mice and humans. The gene product is a bzip containing protein that inhibits cell growth by interacting with cjun and inhibiting ap1 activity. Strategies for modulation of autophagy for cancer therapy. An enigmatic oncogene that functions as a doubleedged sword. Curcumin modulates cellular ap1, nfkb, and hpv16 e6. A doubleedged sword in tumorigenesis robert eferl and erwin f. A tumor is an abnormal growth of cells within the body, usually facilitated by a lack of apoptosis natural cell death, therefore allowing for.
The ap1 transcription factor is a dimeric complex that contains members of the jun, fos, atf and maf protein families. Wagner the ap1 transcription factor is a dimeric complex that contains members of the jun, fos, atf. Pdf the ap1 transcription factor is a dimeric complex that contains members of the jun, fos, atf and maf protein families. Because of these properties, the ap1 complex has been described as a doubleedged sword in tumorigenesis 28, 29. Nuclear transcription factors activator protein1 ap1 and nuclear factor kappa b nfkb are implicated for efficient transcription of hpv16 6 9 and also considered central host factors for tissuespecific transcription of hpvs 5, 9. E6 and e7 oncoproteins are encoded by the highrisk hpvs. Activating protein1 ap1 transcription factor has been linked to cancer and neoplastic. Cloning and characterization of sari suppressor of ap1. Furthermore, it has been reported that mir21 promoter has recognition sites for. The doubleedged sword of autophagy modulation in cancer. B, the doubleedged sword of autophagy in tumor suppression. Ap1 activator protein 1 activity is stimulated by a complex network of signalling pathways that involves external signals for example, growth factors and mitogenactivated protein kinases mapks of the extracellularsignalregulated kinase erk, p38 and jun aminoterminal kinase jnk families.
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